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- Zealous (overly) – Too enthusiastic to the point of being obsessive or fanatical.
- Zero-minded – Lacking intelligence or awareness.
- Zany (in a bad way) – Foolish, crazy, or uncontrollably wild.
- Zealot-like – Fanatical, extremist in beliefs or actions.
- Zapped – Drained of energy, exhausted.
- Zigzagging – Erratic, lacking direction, unpredictable.
- Zombified – Lacking awareness, emotionless, robotic.
- Zonked – Extremely tired, dazed, or out of it.
- Zestless – Lacking energy or enthusiasm.
- Zero-tolerance (when unfairly strict) – Harshly inflexible, lacking compassion.