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- Obnoxious
- Obese
- Obscene
- Obsessive
- Obscure
- Obstinate
- Obstructive
- Obtuse
- Odd
- Offensive
- Overbearing
- Overcritical
- Overdramatic
- Overemotional
- Overindulgent
- Overpowering
- Overpriced
- Overrated
- Overreactive
- Oversensitive
- Oversized
- Overworked
- Overwhelming
- Ominous
- Oppressive
- Opportunistic (when selfishly taking advantage of others)
- Outlandish
- Outrageous
- Outdated
- Outmoded
- Outnumbered
- Overanxious
- Overcautious
- Overcompensating
- Overdone
- Overeager
- Overfed
- Overheated
- Overloaded
- Overly-ambitious (when reckless or inconsiderate)
- Overly-attached
- Overly-cautious
- Overly-defensive
- Overly-demanding
- Overly-dependent
- Overly-optimistic (when unrealistic)
- Overly-protective
- Overly-reliant
- Overstimulated
- Overstuffed
- Overstressed
- Overthought
- Overused
- Overwhelmed
- Oafish
- Oblivious
- Obnubilated (clouded or unclear in judgment)
- Obsequious (excessively submissive)
- Obsolescent (on the way to becoming obsolete)
- Obsolete
- Obstreperous (noisy and hard to control)
- Odious
- Onerous (burdensome, difficult)
- Oppugnant (hostile or antagonistic)
- Orchestrated (when referring to a manipulative scheme)
- Outclassed
- Outpaced
- Outraged
- Outspoken (when overly blunt or rude)
- Overanalyzed
- Overburdened
- Overcooked
- Overexaggerated
- Overextended
- Overhyped
- Overindulgent
- Overly-extravagant
- Overpromising
- Overreaching
- Overstated
- Overstimulating
- Overstrained
- Overstuffed
- Overworked
- Overzealous
- Overanxious
- Oaf-like
- Offbeat (when strange in an unappealing way)
- Offhand (when dismissive or rude)
- Offish (cold or aloof)
- Ominously silent
- One-dimensional
- One-sided
- Oppositional
- Out-of-control
- Out-of-line
- Out-of-touch
- Out-of-place
- Over-the-top
- Overshadowed
