- Damaged
- Damaging
- Damp
- Dangerous
- Dark
- Daunting
- Dazed
- Dead
- Deadly
- Deafening
- Debased
- Debilitating
- Deceitful
- Deceptive
- Declining
- Defamatory
- Defeated
- Defective
- Defenseless
- Defensive
- Deferential (in a weak way)
- Defiant
- Deficient
- Deformed
- Degenerate
- Degrading
- Dejected
- Delicate (in a weak way)
- Delirious
- Deluded
- Delusional
- Demanding
- Demented
- Demoralizing
- Demotivating
- Denied
- Dense (as in not smart)
- Dependent
- Depressing
- Depraved
- Deprived
- Deranged
- Derogatory
- Desolate
- Despairing
- Desperate
- Despicable
- Despondent
- Destitute
- Destructive
- Detached
- Detrimental
- Devalued
- Devastated
- Devilish
- Devious
- Difficult
- Dim
- Diminished
- Dingy
- Dire
- Dirty
- Disadvantaged
- Disagreeable
- Disappointing
- Disapproving
- Disastrous
- Disbelieving
- Discontented
- Discordant
- Discouraging
- Discourteous
- Discrepant
- Disdainful
- Diseased
- Disenchanted
- Disfigured
- Disgruntled
- Disgusting
- Dishonest
- Dishonorable
- Disillusioned
- Disloyal
- Dismal
- Dismissive
- Disorderly
- Disorganized
- Disoriented
- Displeased
- Disposable (in a negative way)
- Disproportionate
- Disreputable
- Disrespectful
- Disruptive
- Dissatisfied
- Distant
- Distasteful
- Distorted
- Distraught
- Distressing
- Distrustful
- Disturbing
- Divisive
- Dizzied
- Doomed
- Doubtful
- Downcast
- Downhearted
- Downtrodden
- Drab
- Drained
- Dreary
- Dreadful
- Dreary
- Drowsy
- Drunk
- Dubious
- Dull
- Dying
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