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- Cacophonous
- Cagey
- Calculating
- Callous
- Camouflaged
- Cantankerous
- Capricious
- Careless
- Catastrophic
- Caustic
- Cautious (in a negative sense)
- Cavalier
- Cheap
- Cheating
- Cheerless
- Childish
- Chilly
- Choleric
- Clammy
- Clashing
- Clingy
- Cloddish
- Clueless
- Clumsy
- Coarse
- Cocky
- Cold
- Cold-blooded
- Cold-hearted
- Colorless
- Combative
- Complacent
- Complaining
- Complicated
- Compulsive
- Conceited
- Condescending
- Conflicted
- Confused
- Confrontational
- Contemptible
- Contemptuous
- Contrary
- Controlling
- Corrupt
- Corrosive
- Cowardly
- Crabby
- Cranky
- Crass
- Craven
- Crazy
- Creepy
- Criminal
- Critical
- Crooked
- Cross
- Cruel
- Crude
- Crummy
- Crusty
- Cumbersome
- Cunning (in a deceitful way)
- Curt
- Cynical
